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What is Dihexa?
Dihexa is a synthetic peptide derived from angiotensin IV, studied for its reported high potency in promoting synaptic connections (synaptogenesis). The literature describes it as extremely potent relative to BDNF in model systems, with limited human data.
How Dihexa works (research mechanism)
Dihexa research focuses on the hepatocyte-growth-factor / c-Met system and synaptogenesis, with interest in memory and cognition endpoints.
Primary research applications
Synaptogenesis research
Studied for formation of new synaptic connections in models.
Memory and cognition research
Examined for learning and memory endpoints.
Neurodegeneration models
Used in exploratory neurodegeneration research.
Research dosing reference
Research references commonly cite 5-10 mg daily in 4-8 week cycled windows. Reference values only - an advanced compound with limited data; use caution.
Reconstitution & handling
Dihexa ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted Dihexa solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted Dihexa vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
Generally studied as a standalone high-potency nootropic.
How Dihexa compares
Dihexa is studied as far more potent than Semax/Selank in model systems but with much less data, making it a specialized research tool.
Safety & research considerations
Dihexa is a research chemical with limited human data and is not approved for human use. For laboratory research only - handle with caution.
Sourcing, purity & Certificate of Analysis
Every lot of Dihexa sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade Dihexa from unverified material - quality is established before the vial ever reaches your lab.
How to order Dihexa for research
Dihexa can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
Why is Dihexa considered high-potency?
The literature reports it as extremely potent for synaptogenesis relative to BDNF in models, though human data is limited. Research use only. Every lot of Dihexa is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC.
What sizes are available?
10 mg and 20 mg vials, third-party tested, COA on request. Dihexa is supplied as a lyophilized (freeze-dried) powder in 10 mg and 20 mg research sizes. A Certificate of Analysis tied to the tracked lot is available on request.
Is Dihexa FDA approved?
No, it is a research chemical, not for human consumption. Dihexa is sold strictly for laboratory and in-vitro research use only; the research-grade material is not an FDA-approved drug product, not a supplement or food, and not for human or animal consumption.
How should Dihexa be stored?
Store un-reconstituted Dihexa vials refrigerated and protected from light; the lyophilized powder is stable enough to tolerate shipping. Once reconstituted, keep the solution at 2-8C away from light, label it with concentration and date, and use it within roughly two to four weeks of research handling.
How is Dihexa purity verified?
Dihexa purity is verified by an independent third-party laboratory, not an in-house claim. Purity is quantified by HPLC against a 99%+ target and identity is confirmed by mass spectrometry, and the resulting Certificate of Analysis is tied to the tracked lot you receive and is available on request.
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External references: Peptides (Wikipedia) · U.S. Food and Drug Administration